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Disseminated medullary thyroid carcinoma despite at the crack thyroid surgery in the multiple endocrine neoplasia -2A syndrome.

Neurocutaneous spectrum of multiple endocrine neoplasia Directory of Open Access Journals Sweden. Full Text Present Multiple endocrine neoplasia type I or Wermer syndrome is characterized by primary hyperparathyroidism, enteropancreatic endocrine tumor, and a pituitary pathology. A year-old male presented with visual field defects, hyperprolactinemia, and hypogonadism. He also had multiple infraumbilical skin-colored nodules. A syndromal association of Wermer syndrome was derived using the dermal, pituitary, parathyroid, and gastrointestinal hormonal manifestations of the tumor.

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CDKN1B mutations and polymorphisms are involved in tumorigenesis; specifically, the VG single nucleotide polymorphism has been linked to different tumours with controversial results. Directory of Open Access Journals Sweden. Novel multiple endocrine neoplasia type 1 variations in patients with sporadic primary hyperparathyroidism. Retinal vascular sheathing was also observed at midperiphery.

Normalization of pituitary hypersecretion was much less frequent in patients with multiple endocrine neoplasia type 1 than in subjects with non- multiple endocrine neoplasia type 1. Multiple sex partner was a frequent antecedent.

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